BackgroundChildhood abuse increases risk for high levels of distress in response to future stressors. Interpersonal social support is protective for health, particularly during stress, and may be particularly beneficial for individuals who experienced childhood abuse.ObjectiveInvestigate whether childhood abuse predicts levels of posttraumatic stress disorder (PTSD) symptoms related to the COVID-19 pandemic, and test whether the perceived availability of social companionship preceding the pandemic moderates this relationship.MethodsDuring Phase 1, adults (N= 120; AgeM[SD] = 19.4 [0.94]) completed a retrospective measure of childhood (...) adversity along with a measure of perceived availability of opportunities for social engagement immediately preceding the pandemic. Two weeks after the COVID-19 pandemic declaration, participants completed the Impact of Event Scale-Revised (IES-R) with respect to the pandemic. Hierarchical linear regression analyses examined the interaction between childhood abuse and the perceived availability of social companionship preceding the pandemic as a predictor of PTSD symptoms.ResultsAdjusting for covariates, the interaction between childhood abuse and perceived availability of others to engage with before the onset of the pandemic was a significant predictor of IES-hyperarousal (β = −0.19,t= −2.06,p= 0.04, ΔR2= 0.032, CI: [−0.31 to −0.01]).ConclusionLevels of perceived opportunities for social companionship before the pandemic associates with levels of hyperarousal related to the pandemic, particularly for individuals who experienced high levels of childhood abuse. More research is needed to understand how to mitigate the higher levels of distress related to the pandemic for these individuals in order to reduce risk for future psychiatric disorders. (shrink)

The Cleveland Clinic Innovation Management and Conflict of Interest (“IM&COI”) Program implemented a policy on Conflicts of Interest in Clinical Practice in 2013. The policy requires review of financial interests greater than $20,000 in a year, or more than 5% equity in a company, when the clinician is prescribing or using products of the company with which they have a relationship. The IM&COI Committee developed definitions for low, medium and high levels of annual compensation and risk and uses a “Matrix” (...) to guide disclosure based on these factors. (shrink)

The ethics of the Flexibility In duty hour Requirements for Surgical Trainees trial have been vehemently debated. Views on the ethics of the FIRST trial range from it being completely unethical to wholly unproblematic. The FIRST trial illustrates the complex ethical challenges posed by cluster randomised trials of policy interventions involving healthcare professionals. In what follows, we have three objectives. First, we critically review the FIRST trial controversy, finding that commentators have failed to sufficiently identify and address many of the (...) relevant ethical issues. The 2012 Ottawa Statement on the Ethical Design and Conduct of Cluster Randomized Trials provides researchers and research ethics committees with specific guidance for the ethical design and conduct of CRTs. Second, we aim to demonstrate how the Ottawa Statement provides much-needed clarity to the ethical issues in the FIRST trial, including: research participant identification; consent requirements; gatekeeper roles; benefit-harm analysis and identification of vulnerable participants. We nonetheless also find that the FIRST trial raises ethical issues not adequately addressed by the Ottawa Statement. Hence, third and finally, we raise important questions requiring further ethical analysis and guidance, including: Does clinical equipoise apply to policy interventions with little or no evidence-base? Do healthcare providers have an obligation to participate in research? Does the power-differential in certain healthcare settings render healthcare providers vulnerable to duress and coercion to participant in research? If so, what safeguards might be implemented to protect providers, while allowing important research to proceed? (shrink)

Background Pragmatic randomized controlled trials are designed to evaluate the effectiveness of interventions in real-world clinical conditions. However, these studies raise ethical issues for researchers and regulators. Our objective is to identify a list of key ethical issues in pragmatic RCTs and highlight gaps in the ethics literature. Methods We conducted a scoping review of articles addressing ethical aspects of pragmatic RCTs. After applying the search strategy and eligibility criteria, 36 articles were included and reviewed using content analysis. Results Our (...) review identified four major themes: 1) the research-practice distinction; 2) the need for consent; 3) elements that must be disclosed in the consent process; and 4) appropriate oversight by research ethics committees. 1) Most authors reject the need for a research-practice distinction in pragmatic RCTs. They argue that the distinction rests on the presumptions that research participation offers patients less benefit and greater risk than clinical practice, but neither is true in the case of pragmatic RCTs. 2) Most authors further conclude that pragmatic RCTs may proceed without informed consent or with simplified consent procedures when risks are low and consent is infeasible. 3) Authors who endorse the need for consent assert that information need only be disclosed when research participation poses incremental risks compared to clinical practice. Authors disagree as to whether randomization must be disclosed. 4) Finally, all authors view regulatory oversight as burdensome and a practical impediment to the conduct of pragmatic RCTs, and argue that oversight procedures ought to be streamlined when risks to participants are low. Conclusion The current ethical discussion is framed by the assumption that the function of research oversight is to protect participants from risk. As pragmatic RCTs commonly involve usual care interventions, the risks may be minimal. This leads many to reject the research-practice distinction and question the need for informed consent. But the function of oversight should be understood broadly as protecting the liberty and welfare interest of participants and promoting public trust in research. This understanding, we suggest, will focus discussion on questions about appropriate ethical review for pragmatic RCTs. (shrink)

BackgroundChildhood adversity is linked to adverse health in adulthood. One posited mechanistic pathway is through physiological responses to acute stress. Childhood adversity has been previously related to both exaggerated and blunted physiological responses to acute stress, however, less is known about the psychological mechanisms which may contribute to patterns of physiological reactivity linked to childhood adversity.ObjectiveIn the current work, we investigated the role of challenge and threat stress appraisals in explaining relationships between childhood adversity and cortisol reactivity in response to (...) an acute stressor.MethodsUndergraduate students completed an online survey that included general demographic information and the Risky Families Questionnaire 24 h before a scheduled lab visit. In the lab, a research assistant collected a baseline salivary cortisol sample. Following the baseline period, participants were read instructions for the Trier Social Stress Test, a validated psychological lab stressor. Next, they completed a challenge vs. threat task appraisal questionnaire and completed the speech and math portion of the TSST. Twenty minutes following the start of the TSST, a second salivary sample was collected to measure changes in salivary cortisol following the TSST.ResultsLinear regression analyses adjusted for age, sex, childhood socioeconomic status, and baseline cortisol levels, showed childhood adversity associated with changes in cortisol levels [B = –0.29 t = –2.35, p = 0.02, R2=0.07]. Linear regression analyses controlling for age, sex, and childhood SES showed childhood adversity associated with both challenge [B = –0.52 t = –5.04, p < 0.001, R2=0.24] and threat [B = 0.55 t = 5.40, p < 0.001, R2=0.27] appraisals. Significant indirect effects of childhood trauma on cortisol reactivity were observed through challenge appraisals [B = –0.01 ], and threat appraisals [B = –0.01 ].ConclusionChildhood adversity may contribute to blunted cortisol reactivity, a pattern of response which is linked to obesity, addiction, and other behavior-related diseases. Our findings suggest that this relationship is in part a product of stress appraisals. (shrink)

This paper builds upon a critically clarified statement of the triune brain concept to set out the conflict systems neurobehavioral model. The model defines the reciprocal algorithms of behavior from evolved brain structure. The algorithms are driven by subjectively experienced behavioral tension as the self‐preservational programming, common to our ancestral vertebrates, frequently tugs and pulls against the affectional program‐ming of our mammalian legacy. The yoking of the dual algorithmic dynamic accounts for the emergence of moral and spiritual consciousness as manifested (...) in the universal norm of reciprocity and in the work of such thinkersas Martin Buber and Paul Tillich. (shrink)

Ethical codes help guide the methods of research that involves samples gathered from ?at-risk? populations. The current article reviews general as well as specific ethical principles related to gathering informed consent from partner violent offenders mandated to outpatient treatment, a group that may be at increased risk of unintentional coercion in behavioral sciences research due to court mandates that require outpatient treatment without the ethical protections imbued upon prison populations. Recommendations are advanced to improve the process of informed consent within (...) this special population and data supporting the utility of the recommendations in a sample 70 partner violent offenders are provided. Data demonstrate that participants were capable of comprehending all essential elements of consent. (shrink)

Paul MacLean, founder and long-time chief ofthe Laboratory of Brain Evolution and Behavior,National Institutes of Health, is a pioneeringfigure in the emergent field of evolutionaryneuroscience. His influence has been widelyfelt in the development of biologicalpsychiatry and has led to a considerableliterature on evolutionary approaches toclinical issues. MacLean's work is alsoenjoying a resurgence of interest in academicareas of neuroscience and evolutionarypsychology which have previously shown littleinterest or knowledge of his extensive work. This chapter builds on MacLean's work to bringtogether new insights (...) into the neuralarchitecture of human development, hierarchy,conflict behavior, and reciprocity in the formof the Conflict Systems Neurobehavioral Model. Hamilton 's rule of kinship altruism orinclusive fitness is proposed to be the gene'seye complement to MacLean's evolutionaryneuroscience and the CSN Model derivedtherefrom. Hierarchy, conflict behavior andreciprocity are also central issues in healthydevelopment as well as in clinical syndromes ofdepression, mania, and other socialmaladjustments. The emerging insights permitthe integration of the concept of inclusivefitness underpinning evolutionary psychologywith MacLean's perspective on evolutionaryneuroscience as well as the definition of newchallenges for mental health and socialstability. The policy implications areindicated. (shrink)

Some of our talk and thought is descriptive; it attempts to say how the world is. Some of our talk and thought is normative; it attempts to say how the world should be. This dissertation addresses the relationship between those two domains. Specifically, I investigate the question: in virtue of what do some descriptive considerations have the normative status of reasons for action? Philosophers working on this question have tended to defend three possible answers: that considerations are reasons in virtue (...) of mind-independent normative facts, in virtue of the desires of the agents for whom they are reasons, or in virtue of the voluntary acts of will of the agents for whom they are reasons. I argue that the best answer is a hybrid of the first and third answers. While it is not always up to us whether some consideration is a reason, sometimes it is. Investigating how this can be turns out to illuminate some classic metaethical issues about the role of reflection in agency, the relationship between morality and our personal projects, and how normative motivation is possible. (shrink)

Quality and service improvement (QSI) research employs a broad range of methods to enhance the efficiency of healthcare delivery. QSI research differs from traditional healthcare research and poses unique ethical questions. Since QSI research aims to generate knowledge to enhance quality improvement efforts, should it be considered research for regulatory purposes? Is review by a research ethics committee required? Should healthcare providers be considered research participants? If participation in QSI research entails no more than minimal risk, is consent required? The (...) lack of consensus on answers to these questions highlights the need for ethical guidance. Three distinct approaches to classifying QSI research in accordance with existing ethical principles and regulations can be found in the literature. In the first approach, QSI research is viewed as distinct from other types of healthcare research and does not require regulation. In the second approach, QSI research falls within regulatory guidelines but is exempt from research ethics committee review. In the third approach, QSI research is deemed to be part of the learning healthcare system and, as such, is subject to a different set of ethical principles entirely. In this paper, we critically assess each of these views. While none of these approaches is entirely satisfactory, we argue that use of the ethical principles governing research provides the best means of addressing the numerous questions posed by QSI research. (shrink)

ObjectivesTo describe reporting of informed consent in pragmatic trials, justifications for waivers of consent and reporting of alternative approaches to standard written consent. To identify factors associated with (1) not reporting and (2) not obtaining consent.MethodsSurvey of primary trial reports, published 2014–2019, identified using an electronic search filter for pragmatic trials implemented in MEDLINE, and registered in ClinicalTrials.gov.ResultsAmong 1988 trials, 132 (6.6%) did not include a statement about participant consent, 1691 (85.0%) reported consent had been obtained, 139 (7.0%) reported a (...) waiver and 26 (1.3%) reported consent for one aspect (eg, data collection) but a waiver for another (eg, intervention). Of the 165 trials reporting a waiver, 76 (46.1%) provided a justification. Few (53, 2.9%) explicitly reported use of alternative approaches to consent. In multivariable logistic regression analyses, lower journal impact factor (p=0.001) and cluster randomisation (p<0.0001) were significantly associated with not reporting on consent, while trial recency, cluster randomisation, higher-income country settings, health services research and explicit labelling as pragmatic were significantly associated with not obtaining consent (all p<0.0001).DiscussionNot obtaining consent seems to be increasing and is associated with the use of cluster randomisation and pragmatic aims, but neither cluster randomisation nor pragmatism are currently accepted justifications for waivers of consent. Rather than considering either standard written informed consent or waivers of consent, researchers and research ethics committees could consider alternative consent approaches that may facilitate the conduct of pragmatic trials while preserving patient autonomy and the public’s trust in research. (shrink)

A key issue in the philosophy of biology is evolutionary contingency, the degree to which evolutionary outcomes could have been different. Contingency is typically contrasted with evolutionary convergence, where different evolutionary pathways result in the same or similar outcomes. Convergences are given as evidence against the hypothesis that evolutionary outcomes are highly contingent. But the best available treatments of contingency do not, when read closely, produce the desired contrast with convergence. Rather, they produce a picture in which any degree of (...) contingency is compatible with any degree of convergence. This is because convergence is the repeated production of a given outcome from different starting points, and contingency has been defined without reference to the size of the space of possible outcomes. In small spaces of possibilities, the production of repeated outcomes is almost assured. This paper presents a definition of contingency which includes this modal dimension in a way that does not reduce it to the binary notion of contingency found in standard modal logic. The result is a conception of contingency which properly contrasts with convergence, given some domain of possibilities and a measure defined over it. We should therefore not ask whether evolution is contingent or convergent simpliciter, but rather about the degree to which it is contingent or convergent in various domains, as measured in various ways. (shrink)

Building on the advances made by feminist reconsiderations of methods, methodology and epistemology, this paper calls for an alliance between feminist social science and the emerging field of queer theory. By challenging traditional scientific approaches to research on sexual minority groups, a distinctly 'queer' approach is advocated that adopts a reflexive position on subjectivity and sexuality. While essentialist approaches privilege gay/lesbian, man/woman, and object/subject, this approach advances a framework of critical sexualities that moves social science into an arena of inclusivity (...) and multiple identities, rather than reductionistic categorical thought. The implications are clear: a rethinking of identity categories that transcend stagnant dualisms. (shrink)

I argue that Thomas Aquinas’s Identity Formula—the statement that the “intellect in act is the intelligible in act”—does not, as is usually supposed, express his position on how the intellect accesses extramental realities (responding to the so-called “mind-world gap”). Instead, it should be understood as a claim about the metaphysics of intellection, according to which the perfection requisite for performing the act of understanding is what could be called “intellectual-intelligible being.” In reinterpreting Aquinas’s Identity Formula, I explore the notion of (...) being “in act” as an intellect or intelligible (intelligibile actu, intellectus actu), his curious comments about an “order” or “genus” of intelligibles, and the relationship of understanding and being-understood. (shrink)

We propose a friendly amendment to integrative experiment design (IED), adversarial-collaboration IED, that incentivizes research teams from competing theoretical perspectives to identify zones of the design space where they possess an explanatory edge. This amendment is especially critical in debates that have high policy stakes and carry a strong normative-political charge that might otherwise prevent free exchange of ideas.

For years, experimental philosophers have attempted to discern whether laypeople find free will compatible with a scientifically deterministic understanding of the universe, yet no consensus has emerged. The present work provides one potential explanation for these discrepant findings: People are strongly motivated to preserve free will and moral responsibility, and thus do not have stable, logically rigorous notions of free will. Seven studies support this hypothesis by demonstrating that a variety of logically irrelevant (but motivationally relevant) features influence compatibilist judgments. (...) In Study 1, participants who were asked to consider the possibility that our universe is deterministic were more compatibilist than those not asked to consider this possibility, suggesting that determinism poses a threat to moral responsibility, which increases compatibilist responding (thus reducing the threat). In Study 2, participants who considered concrete instances of moral behavior found compatibilist free will more sufficient for moral responsibility than participants who were asked about moral responsibility more generally. In Study 3a, the order in which participants read free will and determinism descriptions influenced their compatibilist judgments—and only when the descriptions had moral significance: Participants were more likely to report that determinism was compatible with free will than that free will was compatible with determinism. In Study 3b, participants who read the free will description first (the more compatibilist group) were particularly likely to confess that their beliefs in free will and moral responsibility and their disbelief in determinism influenced their conclusion. In Study 4, participants reduced their compatibilist beliefs after reading a passage that argued that moral responsibility could be preserved even in the absence of free will. Participants also reported that immaterial souls were compatible with scientific determinism, most strongly among immaterial soul believers (Study 5), and evaluated information about the capacities of primates in a biased manner favoring the existence of human free will (Study 6). These results suggest that people do not have one intuition about whether free will is compatible with determinism. Instead, people report that free will is compatible with determinism when desiring to uphold moral responsibility. Recommendations for future work are discussed. (shrink)

Wesley Salmon’s version of the ontic conception of explanation is a main historical root of contemporary work on mechanistic explanation. This paper examines and critiques the philosophical merits of Salmon’s version, and argues that his conception’s most fundamental construct is either fundamentally obscure, or else reduces to a non-ontic conception of explanation. Either way, the ontic conception is a misconception.

Building on the advances made by feminist reconsiderations of methods, methodology and epistemology, this paper calls for an alliance between feminist social science and the emerging field of queer theory. By challenging traditional scientific approaches to research on sexual minority groups, a distinctly ‘queer’ approach is advocated that adopts a reflexive position on subjectivity and sexuality. While essentialist approaches privilege gay/lesbian, man/woman, and object/subject, this approach advances a framework of critical sexualities that moves social science into an arena of inclusivity (...) and multiple identities, rather than reductionistic categorical thought. The implications are clear: a rethinking of identity categories that transcend stagnant dualisms. (shrink)

At the age of sixty, Cory Taylor was dying of melanoma-related brain cancer. With her illness no longer treatable, she began at the start of 2016 to write about her experiences and, in an extraordinary creative surge, wrote what would become Dying: A Memoir. This is a brief and clear-eyed account of what dying taught Cory: amid the tangle of her feelings, she reflects on the patterns of her life, and remembers the lives and deaths of her parents. (...) She tells us why she would like to be able to choose the circumstances of her own death.Dying is about the vulnerability and strength, courage and humility, anger and acceptance that it takes to live a good life and say goodbye to it in peace. (shrink)

Traditional inflationary approaches that specify the nature of truth are attractive in certain ways; yet, while many of these theories successfully explain why propositions in certain domains of discourse are true, they fail to adequately specify the nature of truth because they run up against counterexamples when attempting to generalize across all domains. One popular consequence is skepticism about the efficaciousness of inflationary approaches altogether. Yet, by recognizing that the failure to explain the truth of disparate propositions often stems from (...) inflationary approaches' allegiance to alethic monism, pluralist approaches are able to avoid this explanatory inadequacy and the resulting skepticism, though at the cost of inviting other conceptual difficulties. A novel approach, alethic functionalism, attempts to circumvent the problems faced by pluralist approaches while preserving their main insights. Unfortunately, it too generates additional problems---namely, with its suspect appropriation of the multiple realizability paradigm and its platitude-based strategy---that need to be dissolved before it can constitute an adequate inflationary approach to the nature of truth. (shrink)

The objective of this editorial is to help authors better understand how to contribute to discourse on corporate sustainability and business ethics. We do this in two ways. First, we clarify our expectations for publication in the “Corporate Sustainability and Business Ethics” section at the Journal of Business Ethics (JBE). As section editors at the journal, we want to make explicit the criteria we apply in our decisions to accept or reject a submission. We argue that authors should explicitly reflect (...) upon what corporate sustainability means in the context of their research. We also stress that publishing in JBE requires an explicit central focus on ethics. We do not take a position on how authors must do either of these two, only that it should be done. In short, there are good business ethics papers that do not add to corporate sustainability theory building or practice, and there are good corporate sustainability papers that are not framed in a business ethics discourse. For the “Corporate Sustainability and Business Ethics” section, we expect authors to strive for both. Second, we provide several illustrations of how corporate sustainability research can be framed from a business ethics perspective around three central sustainability constructs: objective function, carrying capacity, and generational sustainability. These examples are not intended to be comprehensive or to bound the range of acceptable research for JBE’s “Corporate Sustainability and Business Ethics” section. Rather, we aim to provide representative examples of potentially publishable research on business ethics and corporate sustainability to spur innovative thinking and constructive discussion. We hope this editorial will help authors better understand what we expect from submissions to the “Corporate Sustainability and Business Ethics” at JBE. (shrink)

Research has examined various cognitive processes underlying ethical decision-making, and has recently begun to focus on the differential effects of specific emotions. The present study examines three self-focused moral emotions and their influence on ethical decision-making: guilt, shame, and embarrassment. Given the potential of these discrete emotions to exert positive or negative effects in decision-making contexts, we also examined their effects on ethical decisions after a cognitive reappraisal emotion regulation intervention. Participants in the study were presented with an ethical scenario (...) and were induced, or not induced, to feel guilt, shame, or embarrassment, and were asked to reappraise, or not reappraise, the situation giving rise to those emotions. Responses to questions about the ethical case were evaluated for the quality of ethical sensemaking, perceptions of moral intensity, and decision ethicality. Findings indicate that guilt, shame, and embarrassment are associated with different sensemaking processes and metacognitive reasoning strategies, and resulted in different perceptions of moral intensity. Additionally, cognitive reappraisal had a negative impact on each of these factors. Implications of these findings for ethical decision-making research are discussed. (shrink)

A large body of the literature on sustainability indicators, assessments and reporting is currently available. However, sustainability performance measurement systems have an insubstantial presence in the literature. Invariably, a sustainability performance measurement system presents the potential for certain trade-offs or opportunity costs for organizations. Extant sustainability platforms and standards are largely silent about how to deal with trade-offs. Utilizing evidence from the literature, as well as contingency factors, this paper seeks to present a heuristic model for establishing trade-offs in corporate (...) sustainability performance measurement systems. Trade-offs in this area revolve around performance measurement, stakeholder management, competitive advantage, as well as the vertical and horizontal integration of the performance platform. This is particularly important for organizations seeking to establish, integrate or expand their environmental management systems into the area of sustainability. As yet, formalistic attempts to deal with trade-offs in sustainability performance measurement systems are infrequent and vague. (shrink)

What is truth? Philosophers are interested in a range of issues involving the concept of truth beginning with what sorts of things can be true. This is a collection of eighteen new and original research papers on truth and other alethic phenomena by twenty of the most promising young scholars working on truth today.

The purpose of this paper is to explore corporate perspectives on the development and use of sustainability reports. Interviews with experts from 35 Canadian corporations were conducted. The research showed that the content of the reports was determined by following standards, conducting an internal evaluation, and other methods. Five corporations were found to develop fully integrated reports, while another 15 included some sustainability aspects in their annual reports. The extent of external stakeholder involvement in the development of the report varied (...) widely, but the majority of the corporations considered stakeholder input. Data collection was handled by a number of different individuals and groups, with sustainability departments often taking a lead role. Twenty-five corporations relied exclusively on internal personnel to write the report, with the remaining corporations using a combination of internal and external writers. A number of key challenges in developing sustainability reports were identified, including timelines, data collection, selecting content, and striking an appropriate balance in reporting. The reports were used internally in a number of different ways, including enhancing employee awareness and engagement and as an internal reference tool. A number of potential future uses of sustainability reports were also mentioned, such as improving the ability to track real-time performance. (shrink)

Analyticity, or the 'analytic/synthetic' distinction is one of the most important and controversial problems in contemporary philosophy. It is also essential to understanding many developments in logic, philosophy of language, epistemology and metaphysics. In this outstanding introduction to analyticity Cory Juhl and Eric Loomis cover the following key topics: The origins of analyticity in the philosophy of Hume and Kant Carnap's arguments concerning analyticity in the early twentieth century Quine's famous objections to analyticity in his classic 'Two Dogmas of (...) Empiricism' essay The relationship between analyticity and central issues in metaphysics, such as ontology The relationship between analyticity and epistemology Analyticity in the context of the current debates in philosophy, including mathematics and ontology Throughout the book the authors show how many philosophical controversies hinge on the problem of analyticity. Additional features include chapter summaries, annotated further reading and a glossary of technical terms making the book ideal to those coming to the problem for the first time. (shrink)

The neuropsychopharmacological methods and theories used to investigate the nature of depression have been viewed as suspect for a variety of philosophical and scientific reasons. Much of this criticism aims to demonstrate that biochemical- and neurological-based theories of this mental illness are defective, due in part because the methods used in their service are consistently invalidated, failing to induce depression in pre-clinical animal models. Neuropsychopharmacologists have been able to stave off such criticism by showing that their methods are context and (...) domain-sensitive, and that the worth of an animal model is relative to its purpose – thereby creating logical space for the question of whether there could ever be a “good” animal model of depression. I contend that this sort of response implicitly leans on Feyerabendian principles in the philosophy of science, and exemplify this connection using a standard taxonomy of behavioral models of depression. I then take one central Feyerabendian principle – methodological and theoretical pluralism – and show how it maps onto the neuropsychopharmacological research tradition as it is currently practiced. (shrink)

This article focuses on the gap and conflicts in Italy between the so-called ‘historical feminists’ of the 1960s and 1970s, and the generation of young women who entered the public and political arena from 1990 onwards. It discusses the absence of a critical and self-critical perspective within the Italian historical feminist tradition, the various political conflicts that emerged before and during the Berlusconi right-wing government at the beginning of 2000 and the absence of an active visible presence of young women (...) in the media and in politics. (shrink)

Scientific models are often said to be more or less general depending on how many cases they cover. In this paper we argue that the cardinality of cases is insufficient as a metric of generality, and we present a novel account based on measure theory. This account overcomes several problems with the cardinality approach, and additionally provides some insight into the nature of assessments of generality. Specifically, measure theory affords a natural and quantitative way of describing local spaces of possibility. (...) The generality of models can be understood as the measure of possibilities to which the models apply. In order to illustrate our view, we consider the example of structural genomics, the ongoing project of building three-dimensional models of biological macromolecules like proteins. Using measure theory, we interpret the practice of homology modeling, where such models are understood to apply widely but imperfectly to the space of possible proteins. (shrink)

Excerpt from Santayana, the Later Years: A Portrait With Letters I am not surprised or displeased that you should be somewhat attracted to the church. It is the great, normal, human solution - too human, I think: but I have less need of the sustaining faith than most people: animal faith is enough for me. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important (...) historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works. (shrink)

A number of authors have claimed that the fact that our universe seems ’fine-tuned’ is evidence that there are many universes. Ian Hacking (1987) raised doubts about inferences to many sequential universes. More recently, Roger White has argued that it is a fallacy to infer that there are many universes, whether existing all at once or sequentially, from the fact that ours is fine-tuned. The upshot of our discussion will be that Hacking is right about the existence of certain fallacious (...) inferences, but that he (and White) are incorrect in their assimilation of arguments for many universes to these fallacious cases. (shrink)

In virtue of what do some considerations count in favor or against actions? Some philosophers have recently been interested in hybrid answers to this question. For instance, it might be that some facts about reasons are brute, and some are explained in terms of agents’ acts of will. Such views face a challenge: they need a story about how reasons grounded in one way combine with reasons grounded in other ways to yield overall verdicts about what to do. This paper (...) assesses the two most prominent accounts of how that happens, and offers an alternative that captures what's most plausible about each. (shrink)

Building on the advances made by feminist reconsiderations of methods, methodology and epistemology, this paper calls for an alliance between feminist social science and the emerging field of queer theory. By challenging traditional scientific approaches to research on sexual minority groups, a distinctly ‘queer’ approach is advocated that adopts a reflexive position on subjectivity and sexuality. While essentialist approaches privilege gay/lesbian, man/woman, and object/subject, this approach advances a framework of critical sexualities that moves social science into an arena of inclusivity (...) and multiple identities, rather than reductionistic categorical thought. The implications are clear: a rethinking of identity categories that transcend stagnant dualisms. (shrink)

Regress arguments show that to do something for a reason, one does not have to have reflectively endorsed that reason. This might seem to establish that reflection does not play a fundamental role in agency. This paper argues that this conclusion rests on too narrow a conception of agency. If agents are not just creatures who act for reasons but also creatures who can take ownership of the reasons for which they act, then there is a central role for reflection (...) to play in agency even if it's not the role that philosophers of action have typically envisioned for it. (shrink)

Logic forms the basis of mathematics and is a fundamental part of any mathematics course. This book provides students with a clear and accessible introduction to this important subject, using the concept of model as the main focus and covering a wide area of logic. The chapters of the book cover propositional calculus, boolean algebras, predicate calculus and completelness theorems with answeres to all of the excercises and the end of the volume. This is an ideal introduction to mathematics and (...) logic for the advanced undergraduate student. (shrink)

This paper is intended to be an interpretation of what I shall venture to call—the deliberate philosophy of Santayana, as outlined in his recent and most penetrating book: Scepticism and Animal Faith. I refrain from employing the battered term metaphysics, because this candid “ lover of wisdom ” has reminded us that his system is not metaphysical, “ except in the mocking literary sense of the word.” What the vulgar, however, understand by the term, he is guilty of offering in (...) this mature work. It is my desire to try and see his philosophy under the searchlight of contemporary discussion;and I shall introduce some remarks of my own on what I consider significant Realistic issues of the day. My philosophy, however, on nearly all conditions, has been formed by, and is in concord with, the system here expounded. (shrink)